Pathogenesis is multifactorial

Multifactorial pathogenesis of falls as a basis for multifactorial interventions.

The Prevalence, Impact, and Multifactorial Pathogenesis of Diabetic Peripheral Neuropathy

Neuropathy is the most common complication associated with diabetes, and sensorimotor diabetic peripheral neuropathy (DPN) is the most common form of diabetic neuropathy. Although prevalence estimates of DPN vary based upon the criteria used for diagnosis, it is generally held that at least 50% of all patients with diabetes have DPN and between 30% and 50% of patients with prediabetes may also ...

post-transplant anemia: treatable multifactorial pathogenesis and negative impact on graft and possibly patient survival

Adolescent idiopathic scoliosis (AIS): a multifactorial cascade concept for pathogenesis and embryonic origin

This paper formulates a novel multifactorial Cascade Concept for the pathogenesis of adolescent idiopathic scoliosis (AIS). This Concept stems from the longitudinal findings of Clark et al. (J Bone Miner Res 29(8):1729-36, 2014) who identified leptin body composition factors at 10 years of age associated with a scoliosis deformity found at 15 years. We interpret these findings in the light of s...

The role of neuropeptides in the multifactorial pathogenesis of acne vulgaris.

BACKGROUND Central or peripheral stress may induce the development of clinical inflammation in the pilosebaceous unit (PSU) leading to the development or to exacerbation of preexisting acne. The presence of a complete corticotropin-releasing hormone (CRH) system has been confirmed in human sebocytes in vitro. CRH is capable to induce lipid synthesis, steroidogenesis and interact with testostero...